H2N2V1, Main, Exploration, bibRecord, 001F19

Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus

Identifieur interne : 001F19 ( Main/Exploration ); précédent : 001F18; suivant : 001F20

Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus

Auteurs : M. L. Herlocher [États-Unis] ; H. F. Maassab ; R. G. Webster [États-Unis]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 1993.

RBID : Pascal:93-0625644

Descripteurs français

KwdFr :
- ARN viral (), Adaptation physiologique, Animaux, Basse température, Chiens, Femelle, Furets, Mutation, Sous-type H2N2 du virus de la grippe A, Séquence nucléotidique, Virus de la grippe A (génétique), Virus de la grippe A (physiologie).
MESH :
- génétique : Virus de la grippe A.
- physiologie : Virus de la grippe A.
Pascal (Inist)
- ARN viral, Adaptation physiologique, Animaux, Basse température, Chiens, Femelle, Furets, Influenzavirus A, Mutation, Souche vaccinale, Adaptation, Froid, Etude comparative, Gène, Mutation, RNA, Sous-type H2N2 du virus de la grippe A, Structure secondaire, Séquence nucléotidique.

English descriptors

KwdEn :
- Adaptation, Adaptation, Physiological, Animals, Base Sequence, Cold, Cold Temperature, Comparative study, Dogs, Female, Ferrets, Gene, Influenza A Virus, H2N2 Subtype, Influenza A virus (genetics), Influenza A virus (physiology), Influenzavirus A, Mutation, RNA, RNA, Viral (chemistry), Secondary structure, Vaccine strain.
MESH :
- chemical , chemistry : RNA, Viral.
- genetics : Influenza A virus.
- physiology : Influenza A virus.
- Adaptation, Physiological, Animals, Base Sequence, Cold Temperature, Dogs, Female, Ferrets, Influenza A Virus, H2N2 Subtype, Mutation.

Abstract

The live cold-adapted (ca) A/AA/6/60 influenza vaccine is being commercially developed for worldwide use in children and is being used as a model for other live vaccines. Although it has been proven safe and immunogenic, the molecular basis of cold adaptation has never been determined. To identify sequence changes responsible for cold adaptation, we have compared the sequence of the master ca vaccine strain to its progenitor wild-type virus, wt A/AA/6/60 E2 (wt2)

Affiliations:

États-Unis

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus</title>
<author><name sortKey="Herlocher, M L" sort="Herlocher, M L" uniqKey="Herlocher M" first="M. L." last="Herlocher">M. L. Herlocher</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Saint Jude children's res. hosp., dep. virology molecular biology</s1>
<s2>Memphis TN 38101</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Memphis TN 38101</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name>
</author>
<author><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R. G." last="Webster">R. G. Webster</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Saint Jude children's res. hosp., dep. virology molecular biology</s1>
<s2>Memphis TN 38101</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Memphis TN 38101</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">93-0625644</idno>
<date when="1993">1993</date>
<idno type="stanalyst">PASCAL 93-0625644 INIST</idno>
<idno type="RBID">Pascal:93-0625644</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000099</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000115</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000099</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000099</idno>
<idno type="wicri:doubleKey">0027-8424:1993:Herlocher M:molecular:and:biological</idno>
<idno type="wicri:Area/Main/Merge">002009</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:8327480</idno>
<idno type="wicri:Area/PubMed/Corpus">000423</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000423</idno>
<idno type="wicri:Area/PubMed/Curation">000423</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000423</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000384</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000384</idno>
<idno type="wicri:Area/Ncbi/Merge">001314</idno>
<idno type="wicri:Area/Ncbi/Curation">001314</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001314</idno>
<idno type="wicri:doubleKey">0027-8424:1993:Herlocher M:molecular:and:biological</idno>
<idno type="wicri:Area/Main/Merge">001F40</idno>
<idno type="wicri:Area/Main/Curation">001F19</idno>
<idno type="wicri:Area/Main/Exploration">001F19</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus</title>
<author><name sortKey="Herlocher, M L" sort="Herlocher, M L" uniqKey="Herlocher M" first="M. L." last="Herlocher">M. L. Herlocher</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Saint Jude children's res. hosp., dep. virology molecular biology</s1>
<s2>Memphis TN 38101</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Memphis TN 38101</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name>
</author>
<author><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R. G." last="Webster">R. G. Webster</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Saint Jude children's res. hosp., dep. virology molecular biology</s1>
<s2>Memphis TN 38101</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Memphis TN 38101</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Proceedings of the National Academy of Sciences of the United States of America</title>
<title level="j" type="abbreviated">Proc. Natl. Acad. Sci. U. S. A.</title>
<idno type="ISSN">0027-8424</idno>
<imprint><date when="1993">1993</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Proceedings of the National Academy of Sciences of the United States of America</title>
<title level="j" type="abbreviated">Proc. Natl. Acad. Sci. U. S. A.</title>
<idno type="ISSN">0027-8424</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation</term>
<term>Adaptation, Physiological</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>Cold</term>
<term>Cold Temperature</term>
<term>Comparative study</term>
<term>Dogs</term>
<term>Female</term>
<term>Ferrets</term>
<term>Gene</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza A virus (physiology)</term>
<term>Influenzavirus A</term>
<term>Mutation</term>
<term>RNA</term>
<term>RNA, Viral (chemistry)</term>
<term>Secondary structure</term>
<term>Vaccine strain</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral ()</term>
<term>Adaptation physiologique</term>
<term>Animaux</term>
<term>Basse température</term>
<term>Chiens</term>
<term>Femelle</term>
<term>Furets</term>
<term>Mutation</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Séquence nucléotidique</term>
<term>Virus de la grippe A (génétique)</term>
<term>Virus de la grippe A (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A virus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adaptation, Physiological</term>
<term>Animals</term>
<term>Base Sequence</term>
<term>Cold Temperature</term>
<term>Dogs</term>
<term>Female</term>
<term>Ferrets</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Mutation</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>ARN viral</term>
<term>Adaptation physiologique</term>
<term>Animaux</term>
<term>Basse température</term>
<term>Chiens</term>
<term>Femelle</term>
<term>Furets</term>
<term>Influenzavirus A</term>
<term>Mutation</term>
<term>Souche vaccinale</term>
<term>Adaptation</term>
<term>Froid</term>
<term>Etude comparative</term>
<term>Gène</term>
<term>Mutation</term>
<term>RNA</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Structure secondaire</term>
<term>Séquence nucléotidique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The live cold-adapted (ca) A/AA/6/60 influenza vaccine is being commercially developed for worldwide use in children and is being used as a model for other live vaccines. Although it has been proven safe and immunogenic, the molecular basis of cold adaptation has never been determined. To identify sequence changes responsible for cold adaptation, we have compared the sequence of the master ca vaccine strain to its progenitor wild-type virus, wt A/AA/6/60 E2 (wt2)</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><noCountry><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name>
</noCountry>
<country name="États-Unis"><noRegion><name sortKey="Herlocher, M L" sort="Herlocher, M L" uniqKey="Herlocher M" first="M. L." last="Herlocher">M. L. Herlocher</name>
</noRegion>
<name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R. G." last="Webster">R. G. Webster</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F19 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001F19 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:93-0625644
   |texte=   Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus

Molecular and biological changes in the cold-adapted "master strain" A/AA/6/60 (H2N2) influenza virus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.